У оквиру семинара Лабораторије за биофизику Института за физику у Београду, у уторак, 10. децембра 2024. године у 11 и 30 у читаоници библиотеке „Др Драган Поповић“, проф. Ендрју Х.А. Клејтон (академски директор истраживачке обуке на Факултету науке, рачунарства и инжењерских технологија, Свинбурн универзитет технологије, Мелбурн, Аустралија) одржаће предавање:
Nagging cells to death
САЖЕТАК:
Recent advancements in optogenetics and microfluidics have made possible the exciting new branch of synthetic biology, where inputs to cells can be controlled in space and time. While in some instances the goal is to replicate normal physiology (e.g. calcium oscillations) in other cases the use of synthetic, non physiological inputs provides information on how cells sense and interpret dynamic environments. In our laboratory we have been using microfluidic approaches to investigate how the frequency of growth factor inputs affects cell behaviour-cell proliferation, cell population decline and cell differentiation. Interestingly epidermal growth factor, a hormone that normally promotes cell survival and proliferation can induce cell population decline at certain frequencies and induce premature differentiation at others. We propose that the intracellular enzyme cascades (ERK, CREB, JNK, AKT) that control different cell outcomes have distinct growth factor driven activation kinetics, which endows them with different band-pass filtering characteristics.
References:
Nguyen H N Tran and Andrew H A Clayton, Transfer function approach to understanding periodic forcing of signal transduction networks, 2023 _Phys. Biol._ 20 035001
Zubaidah Ningsih and Andrew H A Clayton, Does frequency-dependent cell proliferation exhibit a Fano-type resonance? 2020 _Phys. Biol._ 17 044001